(DOWNLOAD) "Urinary Glycosaminoglycan Excretion in Newly Diagnosed Essential Hypertensive Patients (Technical Briefs) (Clinical Report)" by Clinical Chemistry " eBook PDF Kindle ePub Free
eBook details
- Title: Urinary Glycosaminoglycan Excretion in Newly Diagnosed Essential Hypertensive Patients (Technical Briefs) (Clinical Report)
- Author : Clinical Chemistry
- Release Date : January 01, 2000
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 181 KB
Description
Glycosaminoglycans (GAGS) are major components of the basement membranes and play a key role in their molecular organization and function (1-3). Some authors have proposed that increased loss of proteoglycan from glomerular basement membrane (GBM) alters glomerular charge selectivity, which contributes to urinary loss of albumin (4-8). Several clinical studies have shown that the GAG content of human GBM is significantly decreased and that urinary loss of GAG is markedly increased in diabetic patients (7-9). Among the possible mechanisms of diabetic microalbuminuria are decreased synthesis (10) and/or increased loss of GAGS (9,11) from the GBM.